Methionine, Threonine Catabolism to Succinyl-S-CoA

The video tutorial explores the catabolism of methionine and threonine, focusing on their degradation pathways. Methionine catabolism involves enzymes like methionine adenosyl transferase and cystathionine beta synthase, leading to the production of alpha-ketobutyrate. Threonine catabolism involves threonine dehydratase, producing alpha-ketobutyrate as well. The conversion of propionyl CoA to succinyl CoA is detailed, highlighting its role in the TCA cycle and gluconeogenesis. Methionine is glucogenic, while threonine is both ketogenic and glucogenic.

What are the two amino acids primarily discussed in the video regarding their catabolism?

What is the role of methionine adenosyl transferase in methionine catabolism?

Describe the initial step in the catabolism of methionine.

Explain the significance of homocysteine in the degradation pathway of methionine.

What distinguishes cystathionine beta synthase from cystathionine gamma synthase?

How does threonine catabolism begin, and what enzyme is involved?

What is the final product of propionyl CoA catabolism?

Explain the importance of the TCA cycle in the context of amino acid catabolism.

Discuss the role of succinyl CoA in the liver's metabolic processes.

What are the glucogenic and ketogenic properties of threonine and methionine?