Coagulation | The Intrinsic Pathway of Coagulation

The video tutorial explains the roles of high molecular weight kininogen and bradykinin in inflammation and vessel injury. It details the activation of the intrinsic pathway, highlighting the role of von Willebrand factor and platelets in clotting. The function of polyphosphate kinase in activating factor 12 is discussed, followed by an explanation of the coagulation cascade and the common pathway leading to thrombin formation. The importance of the extrinsic pathway in effective clotting is emphasized, with a comparison to the intrinsic pathway.

What are the functions of high molecular weight kininogen in the coagulation process?

Explain the role of von Willebrand factor in platelet adhesion.

Describe the process of platelet activation and aggregation.

What is the significance of polyphosphate kinase in the intrinsic pathway?

How does factor 12 get activated in the intrinsic pathway?

Discuss the role of calcium ions in the activation of clotting factors.

What is the relationship between factor 9 and factor 10 in the coagulation cascade?

What is the common pathway in coagulation, and how does it relate to intrinsic and extrinsic pathways?

Explain the importance of thrombin in the clotting process.

What are the implications of a deficiency in factor 12 on clotting?