Polyol Pathway & Diabetes | The Role of Polyol Pathway in Diabetes Pathogenesis

The video explains the polyol pathway, its role in converting glucose to sorbitol and then to fructose, and its significance in diabetes. It highlights the pathway's activation under high glucose levels and its importance in spermatocytes. The video also discusses the adverse effects of sorbitol accumulation in tissues with low sorbitol dehydrogenase activity, leading to diabetic complications like retinopathy, nephropathy, and neuropathy. Understanding this pathway helps in comprehending diabetes pathogenesis.

Explain the role of aldose reductase in the polyol pathway.

How does high glucose concentration affect the activity of aldose reductase?

What is the main function of the polyol pathway in the context of glucose metabolism?

What are the potential adverse effects of sorbitol accumulation in tissues?

Describe the relationship between diabetic retinopathy and the polyol pathway.