Coagulation | The Extrinsic Pathway of Coagulation

The video explains the intrinsic and extrinsic pathways of blood coagulation, highlighting the roles of various factors like factor 12, tissue factor, and factor 7. It details how these pathways lead to the activation of factor 10 and the conversion of prothrombin to thrombin, which then converts fibrinogen to fibrin, forming a blood clot. The video also discusses the feedback mechanisms that amplify the coagulation process, ensuring rapid clot formation to prevent blood loss.

What is the primary role of the KININOGEN pathway?

• To convert fibrinogen to fibrin

• To activate factor 10

• To produce an inflammatory hormone

• To produce a stable blood clot

Which pathway is primarily responsible for forming a stable blood clot?

• Common pathway

• Extrinsic pathway

• Intrinsic pathway

• KININOGEN pathway

What initiates the extrinsic pathway?

• Conversion of fibrinogen to fibrin

• Activation of factor 11

• Tissue trauma exposing tissue factor

• Factor 12 binding to an anionic surface

What is the main difference between the extrinsic and intrinsic pathways in terms of factor 10 activation?

• The extrinsic pathway requires more steps

• The intrinsic pathway is faster

• The extrinsic pathway is shorter and faster

• Both pathways are equally fast

What is the role of thrombin in the coagulation process?

• To convert fibrinogen to fibrin

• To produce bradykinin

• To activate factor 7

• To bind to tissue factor

How does fibrin function in the coagulation process?

• It activates factor 10

• It forms a meshwork to prevent blood loss

• It binds to tissue factor

• It dissolves in the blood

What is the initial activator of factor 5 in the coagulation process?

• Binding to tissue factor

• Direct activation by thrombin

• A minor pathway

• Activation by factor 7

What is the significance of the positive feedback cycle in coagulation?

• It dissolves fibrin clots

• It prevents the activation of factor 5

• It amplifies the production of thrombin

• It slows down the clotting process

Which factor is responsible for converting prothrombin to thrombin?

• Factor 7

• Factor 10

• Factor 5

• Factor 12

What is the ultimate goal of both the extrinsic and intrinsic pathways?

• To produce bradykinin

• To activate factor 12

• To form a stable blood clot

• To dissolve fibrin