Ras Raf MEK ERK Signaling and the mTOR Pathway | Interactions and Regulation

The video explains the interaction between the Ras RAF MEK Erk and mtor pathways, focusing on how the Ras RAF MEK Erk pathway regulates mtor complex 1. It details the activation process of the Ras RAF MEK Erk pathway, its role in inhibiting TSC1 and TSC2, and the subsequent activation of mtor complex 1. The video also covers the downstream effects of mtor complex 1 activation, such as inhibition of autophagy and promotion of pyrimidine and protein synthesis. Additionally, it highlights the independent effects of the Ras RAF MEK Erk pathway on cell proliferation, survival, and metastasis.

What is the role of the REB protein in the mTOR pathway?

• It activates mTOR complex 1.

• It is activated by TSC proteins.

• It inhibits mTOR complex 1.

• It activates TSC proteins.

Which receptor's activation initiates the Ras RAF MEK Erk pathway?

• PI3 kinase

• REB

• EGFR

• PDK1

How does the Ras RAF MEK Erk pathway inhibit TSC proteins?

• By activating SOS proteins

• By activating PI3 kinase

• By activating mTOR complex 2

• By activating Erk and RSK proteins

What is the role of PI3 kinase in the mTOR activation process?

• It activates TSC proteins.

• It deactivates mTOR complex 1.

• It phosphorylates PIP2 to PIP3.

• It inhibits AKT.

Which protein is directly activated by PDK1 in the mTOR pathway?

• REB

• RSK

• AKT

• Erk

What is one of the downstream effects of mTOR complex 1 activation?

• Deactivation of pyrimidine synthesis

• Inhibition of autophagy

• Activation of autophagy

• Inhibition of protein synthesis

What independent role does the Ras RAF MEK Erk pathway play in the cell?

• It inhibits cell proliferation.

• It activates genes for cell survival and metastasis.

• It deactivates mTOR complex 1.

• It inhibits pyrimidine synthesis.