Quiz 4

Which of the following explain tumor cells immortality?

• Increased senescence and decreased mitotic crisis

• loss of telomerase activity

  and increased senescence

• Increase mitotic crisis and decreased senescence

• Decreased senescence and increased telomerase activity

The main mechanism of Apoptosis evasion in cancer is

• Mutation of BCL2

• Mutation of BAX

• Mutation of extrinsic apoptosis pathway genes

• Mutation of TP53

In angiogenesis in tumors, hyoxia induced factor activates the transcription of bFGF and .......... which are potent angiogenic factors

Which of the following is preferred by cancer cells when they recieve glucos?

• Aerobic glycolysiss

• Anaerobic glycolysis

• Oxidative phosporylation

• Mitochondrial glycolysis

......... effect is the phenomenon that explains malignant tumor metabolism, and is the base of PET scan

Insensitivity to growth-inhibitory signals in cancer is due to loss of:

• Protoncogenes

• Proapoptotic genes

• Antiapoptotic genes

• Tumor suppressor genes

which of the followings the first event in the process of tumor metastasis

• 
  

  Loss of ell-cell contacts

• Matrix metalloprotease release

• Basement membranes and interstitial matrix degradation

• Inactivation of E-cadherin

• Invasion