BIOC2 Week 1: beta oxidation & ketones

Which of the following cofactors are required for even-chain beta-oxidation?

• B2

• B3

• B5

• B7

• B12

Peroxisomal beta-oxidation produces ____________ ATP than mitochondrial beta-oxidation.

• less

• more

• equal

A 4-month-old child exhibited extreme tiredness, irritable moods, poor appetite, and vomiting and muscle weakness associated with fasting.

Blood test showed elevated levels of circulating free fatty acids. A muscle biopsy demonstrated a significant level of AcylCoA in the cytoplasm, but low levels of acylcarnitine.

The most likely molecular defect in this child is in which one of the following enzymes?

• Acyl CoA synthetase

• CAT II

• CAT I

• hormone sensitive lipase

Ketolysis occurs in the following tissues except...

• brain

• muscle

• RBCs

• liver

• kidney

Type 1 DM is caused by a decreased ability of the β cells of the pancreas to produce insulin. A person with type 1 DM who has neglected to take insulin injections will exhibit which one of the following?

• Increased fatty acid synthesis from glucose in liver

• Decreased conversion of fatty acids to ketone bodies

• Increased stores of triacylglycerol in adipose tissue

• Increased glucose transport into muscle cells

• Increased production of acetone