Platelets and Blood Clotting Assignment

Which of the following substances is found in

the dense granules of platelets?

• Platelet-derived Growth Factor

• von Willebrand factor

• Serotonin

• Fibrinogen

Which of the following statements is correct regarding the platelet membrane?

• The lipid layer is comprised mainly of phospholipids

• Thrombin facilitates binding to sub-endothelium

• Platelet phospholipid facilitates binding of Factor XII

• Thromboxane is made from membrane glycoproteins

Which of the following substances promotes platelet activation?

• Protein S

• Prostacyclin

• Nitric Oxide

• ADP

What is the three step process that stops blood flowing from a cut called?

• haemostasis

• homeostasis

• coagulation

• agglutination

What is the name of the protein that is released by platelets in response to an injury?

• haemoglobin

• glucose

• fibrin

• carbon dioxide

The exposure of tissue factor to blood starts which process?

• platelet adhesion

• platelet aggregation

• the coagulation cascade

• vasoconstriction

What is the name of the soluble factor that results in fibrinolysis?

• plasmin

• tissue plasminogen activator

• fibrin degradation product

• alpha 2 antiplasmin

Which pathway is represented by the diagram shown?

• Extrinsic pathway

• Intrinsic pathway

• Common pathway

• none of the above

Which of the following clotting factors are activated by thrombin? Select all that apply

• Factor V

• Factor X

• Factor XIII

• Factor XI

A 4-year-old male is seen at the University Hospital for recurrent joint bleeds. Coagulation tests revealed: PT 14/11 sec, PTT 47/29 sec. Which of the following coagulation factor deficiencies is compatible with this result?

• Factor X

• Factor IX

• Factor V

• Factor XIII