Chapter 11 Review

What is the minimal percentage of blasts required for AML diagnosis according to the WHO?

• 10%

• 15%

• 20%

• 30%

Which leukemia subtype is associated with the t(15;17) translocation?

• Acute myelomonocytic leukemia

• Acute lymphoblastic leukemia

• Acute promyelocytic leukemia

• Acute megakaryoblastic leukemia

Which cytochemical stains are characteristically positive in AML?

• PAS, SE

• MPO, SBB, specific esterase

• TdT, NSE

• NSE, PAS

Auer rods are composed of which component?

• DNA

• Fused primary granules

• Mitochondria

• Membrane proteins

The CD marker most often positive in T-ALL is:

• CD10

• CD19

• CD7

• CD41

Which leukemia is predominantly seen in children?

• AML

• CML

• ALL

• CLL

What is a classic symptom triad in acute leukemia?

• High fever, weight gain, polycythemia

• Anemia, infection, bleeding

• Splenomegaly, hypoglycemia, lymphadenopathy

• Bone pain, rash, vomiting

Which cytogenetic abnormality is linked to a good prognosis in AML?

• t(9;22)

• t(8;21)

• t(12;21)

• t(1;19)

What blast percentage is required for ALL diagnosis by WHO criteria?

• 5%

• 10%

• 20%

• 25%

What is the approximate complete remission rate for pediatric ALL?

• 50%

• 65%

• 85%

• 100%