Drug Discovery Review 2

Front

What is the main goal of Phase 1 clinical trials?

Back

To test the tolerable drug dose versus a toxic drug dose in healthy participants.

Front

How many participants are typically involved in Phase 1 clinical trials?

Back

20-80 participants.

Front

What ethical principle is violated by selectively withholding risks from clinical trial participants?

Back

Informed consent and transparency.

Front

How do you prepare a stock solution from a concentrated solution?

Back

Dilute the concentrated solution to the desired concentration using a solvent.

Front

What is the significance of standard deviations in comparing experimental results?

Back

Results should be compared outside of 2 standard deviations to determine significance.

Front

What is the purpose of Phase 2 clinical trials?

Back

To assess the drug's efficacy and side effects in a larger group of patients.

Front

What is the typical participant range for Phase 3 clinical trials?

Back

1,000-3,000 participants.

Front

What is the role of a positive control in a clinical trial?

Back

To provide a benchmark for comparison against the experimental treatment.

Front

What does 'bioethics' refer to in the context of clinical trials?

Back

The study of ethical issues arising from biological and medical research.

Front

What is the difference between a positive control and a negative control?

Back

A positive control shows the expected effect, while a negative control shows no effect.