In this episode, Leslie Samuel discusses peripheral resistance, a key factor in the cardiovascular system. He explains how blood flow encounters resistance due to friction with blood vessel walls and how this resistance can be regulated. The focus is on arterioles, which can constrict or dilate to change resistance levels. Hormones like epinephrine and norepinephrine play roles in vasodilation and vasoconstriction, affecting peripheral resistance and mean arterial pressure. The episode also covers the impact of atherosclerosis, where plaque buildup increases resistance and blood pressure. Leslie concludes with health advice to maintain a healthy lifestyle.

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