Purine Catabolism: Conversion of Hypoxanthine to Uric Acid

The video tutorial explores the catabolism of nucleic acids, focusing on purine breakdown. It begins with adenosine conversion to inosinate and hypoxanthine, followed by the conversion of hypoxanthine to uric acid using xanthine oxidase. The enzyme's mechanism is detailed, highlighting the role of coenzymes like molybdenum coenzyme, FAD, and NAD. The tutorial also covers electron transfer processes and the regeneration of coenzymes, emphasizing the enzyme's dual activity in different settings.

What are the two sequential steps involved in the catabolism of hypoxanthine?

Discuss the homeostatic imbalances associated with urate accumulation.

What is the role of iron-sulfur centers in the mechanism of xanthine oxidase?

Describe the mechanism of electron transfer in xanthine oxidase.