Vitamin D | Biosynthesis & the Vitamin D Receptor

The video explains the biosynthetic pathway of vitamin D, highlighting its sources, including dietary intake and de novo synthesis. It details the role of 7-dehydrocholesterol in cholesterol and vitamin D synthesis, emphasizing the non-enzymatic reactions driven by sunlight. The conversion of cholecalciferol to active vitamin D (calcitriol) is discussed, along with its physiological effects, such as promoting insulin sensitivity and reducing inflammation. The mechanism of the vitamin D receptor is explored, and the impact of statins on vitamin D synthesis is addressed.

What are the two primary sources from which we can obtain vitamin D?

Explain the term 'de novo' in the context of vitamin D synthesis.

What role does 7-dehydrocholesterol play in the synthesis of vitamin D?

Describe the non-enzymatic reactions involved in the first steps of vitamin D synthesis.

What is the significance of UV light in the conversion of 7-dehydrocholesterol to pre-vitamin D?

How does the synthesis of vitamin D differ in high latitude regions?

What is the role of the liver in the metabolism of cholecalciferol?

Explain the process by which calcitriol exerts its effects on the body.

What are the potential consequences of vitamin D deficiency?

How do statin medications affect vitamin D synthesis?