You’re Not a Lab Mouse, but You Might Be a Wild Mouse

The video discusses the limitations of using inbred lab mice for health research, particularly in immune system studies. It highlights the genetic uniformity of lab mice, which makes them less representative of human biology. Wild mice, with their genetic diversity and exposure to various pathogens, offer more human-like immune responses. Researchers are exploring new models like the Collaborative Cross and Diversity Outbred mice to bridge the gap between lab mice and humans, aiming for more accurate and applicable research outcomes.

Explain the challenges faced when translating treatments from lab mice to humans.

Discuss the significance of genetic variation in wild mice compared to inbred lab mice.

What are diversity outbred mice and how do they contribute to research?