Proline and Arginine Catabolism to Glutamate Semialdehyde

The video discusses the degradation of arginine and proline into glutamate gamma semi aldehyde. It explains the role of enzymes like arginase and ornithine transcarbamoylase in arginine degradation. The video also covers proline degradation, focusing on proline oxidase and its role in apoptosis, highlighting the generation of reactive oxidative species and the involvement of P53 protein.

Which two amino acids are degraded to form glutamate gamma semi-aldehyde?

• Arginine and Proline

• Valine and Threonine

• Lysine and Methionine

• Leucine and Isoleucine

What enzyme is involved in the urea cycle and also in the degradation of arginine?

• Glutaminase

• Ornithine transcarbamoylase

• Arginase

• Transaminase

What is the unique feature of the transamination process involving ornithine?

• It uses the delta amine

• It forms a ketone

• It produces ammonia

• It occurs in the cytosol

What is apoptosis?

• Programmed cell death

• Cell division

• DNA replication

• Protein synthesis

Which protein is upregulated during apoptosis and induces cell death?

• Caspase 9

• P53

• Cytochrome C

• Ubiquinone

What is the role of proline oxidase in apoptosis?

• Inhibits cell division

• Repairs DNA

• Activates P53

• Synthesizes reactive oxidative species

What is the immediate product of proline dehydrogenation?

• D1 pyrroline 5 carboxylate

• Urea

• Glutamate

• Ornithine

Which molecule can act as a terminal electron acceptor in proline oxidase?

• ATP

• NADH

• Ubiquinone

• Glucose

What is superoxide?

• A protein synthesis inhibitor

• A DNA repair enzyme

• A type of amino acid

• A reactive oxidative species

How is proline oxidase potentially linked to mental health disorders?

• It enhances protein synthesis

• It inhibits cell division

• It increases DNA replication

• Deficiency may affect apoptosis