Ras Raf MEK ERK Signaling Pathway - Overview, Regulation and Role in Pathology

The video provides an overview of the Ras RAF MEK Erk pathway, a MAPK cascade crucial for cell proliferation, survival, and metastasis. It explains the roles of Ras, RAF, MEK, and Erk, detailing how the pathway operates and its regulation by factors like EGFR and TGF alpha. The pathway's significance in cancer pathogenesis is highlighted, emphasizing its role in cell proliferation and survival. The video concludes with a promise to explore the pathway's involvement in cancer in future lessons.

What type of cascade is the Ras RAF MEK Erk pathway classified as?

• Cytokine cascade

• Apoptotic cascade

• GTPase cascade

• MAPK cascade

Which protein is directly activated by Ras in the pathway?

• MEK

• ERK

• RAF

• EGFR

What is the role of ERK once it is activated in the pathway?

• It binds to EGFR

• It inhibits cell proliferation

• It translocates to the nucleus and activates genes

• It deactivates transcription factors

Which receptor is a main regulator of Ras at the beginning of the pathway?

• TGF alpha

• EGFR

• SRC

• P20

How can the Ras RAF MEK Erk pathway auto-activate itself?

• By deactivating GRB2

• By transcribing more TGF alpha

• By inhibiting SOS

• By producing more EGFR

Which protein can regulate RAF in the pathway?

• EGFR

• SRC

• TGF alpha

• ERK

Why is the Ras RAF MEK Erk pathway significant in cancer pathogenesis?

• It inhibits cell survival

• It deactivates transcription factors

• It promotes cell proliferation, survival, and metastasis

• It reduces metastasis