Reproducibility in Research: An Introduction

The video discusses the challenges of reproducibility in scientific research, highlighting issues such as bias, publication pressure, and the difficulty of replicating studies. It presents case studies from Amgen, Bayer Healthcare, and psychology, showing low replication rates. The video also explores solutions, including better review processes, trial registration, and initiatives by organizations like the NIH to enhance data reproducibility.

What is one way to define a scientific result as correct?

• When it receives funding from a major institution

• When it is based on a novel hypothesis

• When it can be reproduced by others

• When it is published in a high-profile journal

What percentage of the 53 landmark cancer studies were successfully replicated by Amgen?

• 75%

• 11%

• 25%

• 50%

What is a common reason for the failure to replicate scientific studies?

• Insufficient sample size

• Bias towards publishing positive results

• Outdated technology

• Lack of funding

What is a potential consequence of the current replication crisis in science?

• More collaboration among scientists

• Wasted resources and loss of faith in science

• Greater public trust in scientific findings

• Increased funding for research

Which organization is encouraging transparency and registration in scientific research?

• World Health Organization

• Open Science Project

• American Medical Association

• National Science Foundation

What are the four domains the NIH is focusing on to enhance data reproducibility?

• Research ethics, data sharing, publication, funding

• Data collection, peer review, publication, funding

• Experimental design, laboratory practices, analysis and reporting, culture of science

• Hypothesis generation, data analysis, publication, peer review

What is the main goal of the training modules discussed in the video?

• To increase the number of published papers

• To improve the quality and reproducibility of scientific research

• To reduce the cost of scientific experiments

• To promote competition among scientists