Melanin Physiology: Conversion of Dopachrome to Dihdroxyindole

The video explores the synthesis of melanin, focusing on the role of enzymes like tyrosinase and the formation of pre-monomers such as DHCA and DHI. It explains the function of melanocytes and melanosomes in melanin production and delves into the non-enzymatic reaction mechanism that converts DOPA Chrome to DHI. The video also discusses the organic chemistry behind the reaction, highlighting the importance of aromaticity and the spontaneous nature of the process.

What is the primary function of melanin in the body?

• To provide energy

• To regulate temperature

• To protect DNA

• To aid in digestion

Which enzyme is responsible for converting pre-monomers into active monomers in melanin synthesis?

• Melanase

• Tyrosinase

• Hydrolase

• DOPA Chrome isomerase

What is the role of DOPA Chrome in melanin synthesis?

• It is a waste product

• It is a branch point molecule

• It is the final product

• It inhibits melanin production

Where do the processes of melanin synthesis primarily occur?

• In the liver

• In the melanocyte

• In the kidney

• In the bloodstream

What is the significance of the non-enzymatic reaction in melanin synthesis?

• It produces energy

• It requires a catalyst

• It is spontaneous and does not require an enzyme

• It is the slowest step

What is the driving force behind the non-enzymatic conversion of DOPA Chrome to dihydroxy indole?

• Increase in temperature

• Formation of aromatic rings

• Presence of a catalyst

• Decrease in pressure

What is the role of water in the non-enzymatic reaction discussed?

• It acts as an acid

• It is a byproduct

• It acts as a base

• It is not involved

What is the main reason for the stability of the final product in the non-enzymatic reaction?

• Low temperature

• High energy input

• Formation of stable aromatic rings

• Presence of a catalyst

What is the next topic to be discussed after the non-enzymatic reaction?

• Enzyme inhibition

• DOPA Chrome isomerase mechanism

• Role of keratinocytes

• Melanin degradation

What type of reaction is the conversion of DOPA Chrome to dihydroxy indole?

• Endothermic

• Catalytic

• Non-enzymatic

• Enzymatic