PRPP Synthetase Function

The video tutorial explains the synthesis and role of PRPP (phosphoryl pyrophosphate) in nucleotide formation. It details how PRPP is derived from ribose 5 phosphate via the pentose phosphate pathway and its importance in purine and pyrimidine synthesis. The tutorial also covers the configuration of PRPP, emphasizing the SN2 reaction mechanism for nitrogenous base addition, and discusses the regulation of PRPP synthetase.

What is the main precursor to all nucleotides discussed in the video?

• Adenine

• Phosphoryl pyrophosphate (PRPP)

• Ribose 5-phosphate

• Deoxyribose

From which pathway is ribose 5-phosphate derived?

• Glycolysis

• Citric Acid Cycle

• Pentose Phosphate Pathway

• Electron Transport Chain

In what configuration is PRPP found, and why is this important?

• Beta configuration, for stability

• Alpha configuration, for SN2 reaction

• Delta configuration, for solubility

• Gamma configuration, for energy storage

What type of reaction mechanism is primarily involved in the addition of nitrogenous bases to PRPP?

• SN1

• E2

• SN2

• E1

What is the role of PRPP synthetase in nucleotide synthesis?

• It synthesizes deoxyribose

• It removes phosphate groups from nucleotides

• It adds nitrogenous bases to nucleotides

• It converts ribose 5-phosphate to PRPP