TEST 1 MLTH 3713

Which type of hemoglobinopathy occurs when the body failed to synthesize the alpha or beta globin?

• Thalassemia

• Sickle cell trait

• Sickle cell anemia

• Hereditary persistence of fetal Hb

Which complication occurs as a result of vaso-occlusive crisis?

• Ataxia

• Tissue necrosis

• Cessation of erythropoiesis

• Formation of hemoglobin crystals in blood

The condition where bone marrow temporarily stops producing red blood cells is called:

• aplastic crisis

• hemolytic crisis

• vaso-occlusive crisis

• splenic sequestration crisis

What is the BEST test to diagnose hemoglobinopathies?

• RBC count

• Hematocrit analysis

• Sickling test

• Hemoglobin analysis

Which observation characterizes sideroblastic anemia?

• Low levels of serum iron

• Large and pale RBCs

• Appearance of ring sideroblasts

• Appearance of RBCs containing Hb remnants

Acquired clonal sideroblastic anemia occurs due to:

• myelodysplastic syndrome.

• mutation in the ALAS2 gene.

• inability to absorb iron from food.

• deficiency of Vitamin B12 and folate.

Which of the following is a type of hereditary sideroblastic anemia?

• Lead poisoning

• Mutation in G6PD gene

• Mutation in ALAS2 gene

• Deficiency of Vitamin B12

Which of the following may lead to anemia in patients with chronic kidney disease (CKD)?

• Damage of RBC by antibodies

• Lack of erythropoietin released

• Bleeding into gastrointestinal tract

• Excessive release of inflammation proteins

What is the mechanism of anemia in patients with liver disease?

• Damage of RBC by antibodies

• Lack of erythropoietin production

• Bleeding into gastrointestinal tract

• Excessive release of inflammatory protein

Which substance is normally produced by kidney to stimulate red blood cells production?

• Hepcidin

• Interleukin

• Erythropoietin

• Inflammatory proteins