Pharmacology Quiz

Mechanism of action of local anesthetics:

• Block sodium channels thereby stopping axonal conduction

• Blocks alpha and beta receptor

• Block neuronal firing by decreasing Ach in the neuromuscular junction

• Inhibition of acetylcholinesterase enzyme

• Inhibition of enzyme responsible for pain response5

The following are factors that affect the absorption of drug from the gastrointestinal (Gi) tract except:

• Surface area of absorption

• Blood flow to the site of absorption

• Physical state of the drug

• Concentration of the drug at the site of absorption

• Protein binding

Continued stimulation of cells with agonists generally results in which of the following?

• Desensitization

• Up-regulation

• Down-regulation

• A and B

• A and C

Drug that lacks intrinsic efficacy but retains affinity and competes with the agonist for the binding site on the receptor.

• Competitive antagonist

• Full agonist

• Non-competitive antagonist

• Partial antagonist

• Partial agonist

This type of drug produces its effect by binding a site on the receptor distinct from that of the primary agonist and thereby changing the affinity of the receptor for the agonist.

• Competitive antagonist

• Full agonist

• Non-competitive antagonist

• Partial agonist

• Partial antagonist

In this type of study, participants are blinded to treatment assignment, but investigators are not.

• Double blind study

• Single blind study

• Masking

• Open-label

• Un-blinded study

The neurotransmitter of all preganglionic autonomic fibers, and all postganglionic parasympathetic fibers:

• Norepinephrine

• Noradrenaline

• Acetylcholine

• A and B

• A and C

The release of ach and other neurotransmitters by exocytosis is inhibited by:

• Acetylcholinesterase

• Botulinum toxin

• Reserpine

• Metyrosine

• Guanethidine

All of the blowing are enzymes involved in the biosynthesis of epinephrine from tyrosine EXCEPT:

• Tyrosine hydroxylase

• Aromatic L-amino acid decarboxуlase

• Dopamine Beta-hydroxylase

• Phenylethanolamine-N-Methyl transferase

• Monoamine oxidase

Rate limiting enzyme in the synthesis of catecholamines:

• Tyrosine hydroxylase

• Aromatic L-amino acid decarboxуlase

• Dopamine Beta-hydroxylase

• Phenylethanolamine-N-Methyl transferase

• COMT