HIV and Immune Systems Part 1

T/F: AIDS was first recognized in the mid-'81 when clusters of gay patients had developed ​

• TRUE

• FALSE

Which of the following is a co-receptor that facilitates HIV entry into host cells?

• CXCL8

• CCR5

• IL-2

• CD8

What is the primary target of HIV in the human immune system?

• B Cells

• CD8+ T cells

• CD4+ T helper cells

• Natural Killer Cells

What is the normal range of CD4+ T cell count in a healthy individual?

• 200–400 cells/mm³

• 500–800 cells/mm³

• 800–1100 cells/mm³

• 1100–1400 cells/mm³

Which of the following is true about HIV-2?

• It is more common globally than HIV-1

• It is sensitive to NNRTIs

• It is primarily found in Western Africa

• It progresses faster than HIV-1

What is the mechanism of action of NRTIs (Nucleoside Reverse Transcriptase Inhibitors)?

• Inhibit protease enzyme

• Block viral entry into the cell

• Inhibit reverse transcriptase by mimicking nucleosides

• Prevent integration of viral DNA into host genome

Which of the following drugs is associated with a hypersensitivity reaction linked to HLA-B*5701?

• Tenofovir

• Emtricitabine

• Abacavir

• Zidovudine

Which antiretroviral class prevents the integration of viral DNA into the host genome?

• Protease Inhibitors

• NNRTIs

• Integrase inhibitors

• Fusion Inhibitors (entry inhibitors)

What is the most common mode of HIV transmission globally?

• blood transfusion

• mother-to-mother transmission

• sexual contact

• Needle stick injuries

Which HIV envelope glycoprotein is responsible for binding to the CD4 receptor?

• gp41

• gp120

• p24

• gp160