Quiz on Mutation and Gene Editing (HL)

What is a mutation?

• A change in the DNA or RNA base sequence

• A type of gene therapy

• A method of gene editing

• A form of natural selection

What type of mutation occurs when one nucleotide is replaced by another?

• Substitution mutation

• Deletion mutation

• Frameshift mutation

• Insertion mutation

What is a consequence of a base substitution mutation?

• It always results in a stop codon

• It may create a single-nucleotide polymorphism

• It cannot change the amino acid sequence

• It leads to a frameshift mutation

What is a frameshift mutation?

• A mutation that only affects somatic cells

• A mutation that occurs in germ cells only

• A mutation that adds or removes nucleotides not in multiples of three

• A mutation that changes one nucleotide

Which of the following is a mutagen?

• A type of amino acid

• A type of protein

• A chemical that damages DNA

• A form of RNA

What is the role of CRISPR-Cas9 in gene editing?

• To replicate DNA

• To cut DNA at specific locations

• To repair damaged proteins

• To synthesize RNA

What is a single-nucleotide polymorphism (SNP)?

• A mutation that occurs only in somatic cells

• A type of frameshift mutation

• A change in a single nucleotide that may alter a protein

• A mutation that affects multiple genes

What is the consequence of mutations in germ cells?

• They can lead to cancer

• They can be inherited by the next generation

• They only affect somatic cells

• They are not passed to offspring

What is the primary source of genetic variation?

• Natural selection

• Gene editing

• Gene knockout

• Mutations

What is the function of guide RNA (gRNA) in CRISPR technology?

• To cut DNA

• To replicate genes

• To target specific DNA sequences

• To repair mutations