Cell Senescence

What is the primary function of senolytics?

• Prevent cells from becoming senescent

• Promote the secretion of SASP to boost immune response

• Selectively destroy senescent cells

• Extend healthspan by stimulating cell division

How do senomorphics differ from senolytics?

• Senomorphics prevent cells from entering senescence, while senolytics destroy senescent cells

• Senomorphics suppress harmful secretions from senescent cells, while senolytics eliminate SCs

• Senomorphics only work on cancer cells, while senolytics work on all aging cells

• Senomorphics increase SASP production, while senolytics decrease it

Cells become senescent in response to...

• Telomere elongation, oxidative stress, and exposure to radiation

• DNA damage, oncogene activation, and mitochondrial dysfunction

• Increased ATP production, reduced oxidative stress, and enhanced DNA repair

• Overactive stem cell division, leading to exhaustion and permanent cell cycle arrest

What is the primary role of p53 in cellular processes?

• It promotes uncontrolled cell division in response to DNA damage

• It regulates cell cycle arrest, allowing cells to repair damage or undergo senescence or death

• It enhances metabolic activity to prevent oxidative stress and nutrient deficiency

• It directly triggers apoptosis in response to oncogenic signaling

What happens to cells after experiencing DNA damage?

• The cells continue dividing uncontrollably, leading to tumor formation

• All cells undergo apoptosis immediately after DNA damage

• Some cells enter cell cycle arrest and secrete inflammatory factors and growth factors

• The cells repair all DNA damage and resume normal function

What was the name of the movie referenced throughout the presentation?

• The Ace of Adaline

• The Age of Adelien

• The Age of Adaline

• The Age of Adelaide

What was the result of the clinical trial involving rapamycin?

• Increased collagen type 6 levels, increased expression of p16ink4a

• Increased collagen type 6 levels, improved clinical appearance of skin

• Improved clinical appearance of skin, increased expression of p16ink4a

• Increased collagen type 7 levels, improved clinical appearance of skin

What was a key finding in clinical trials using Dasatinib and Quercetin for senescent cell clearance?

• Increased levels of p16ink4a, which slowed down aging

• Complete reversal of aging in human participants

• Reduced expression of p16ink4a, linked to decreased cell senescence

• A rise in collagen production and increased inflammation