Chapter 3_Antigen Presentation

Which cells are primarily responsible for capturing antigens and presenting them to T cells?

• B cells

• Dendritic cells

• Neutrophils

• Eosinophils

Which MHC molecule is recognized by CD8+ T cells?

• MHC Class I

• MHC Class II

• Both MHC Class I and II

• None of the above

What is the primary function of MHC molecules?

• To produce antibodies

• To capture antigens

• To display peptide antigens for recognition by T lymphocytes

• To destroy infected cells

Which component is required for the transport of peptides into the ER for MHC Class I presentation?

• TAP (Transporter associated with Antigen Processing)

• CLIP

• Tapasin

• HLA-DM

Which cell type primarily produces Type I interferons in antiviral responses?

• Classical dendritic cells (cDCs)

• Plasmacytoid dendritic cells (pDCs)

• Macrophages

• B cells

What is the role of the invariant chain in MHC Class II molecules?

• It stabilizes the peptide-MHC complex.

• It binds peptides in the ER.

• It prevents premature peptide binding in the ER.

• It helps with antigen processing.

Which APCs are responsible for displaying antigens to germinal center B cells?

• Macrophages

• Plasmacytoid dendritic cells

• Follicular dendritic cells

• Neutrophils

Which antigen processing pathway is associated with MHC Class II molecules?

• Endogenous antigen processing

• Exogenous antigen processing

• Cross-presentation

• Cytosolic antigen processing

What is cross-presentation?

• Presentation of extracellular antigens by MHC Class I molecules

• Presentation of intracellular antigens by MHC Class II molecules

• Presentation of self-antigens

• Presentation of bacterial DNA

What happens to MHC Class I molecules that do not bind peptides?

• They are transported to the cell surface.

• They are degraded in the ER.

• They bind CLIP peptides.

• They present antigens to CD4+ T cells.