522 Study Group #4

True or False: Normal hemostasis functions to maintain blood in a fluid state, yet also permit the rapid formation of a clot at the site of a vascular injury?

• True

• False

True or False: Clotting can ONLY occur during life.

• True

• False

Select all that apply: How does blood stay naturally thin under normal circumstances?

• 1. Inhibiting platelet adherence and aggregation via NO and PGI2

• 1. Preventing coagulation via heparin like molecules

• 1. Lysing blood clots that may form by t-PA and u-PA

• 1. Activation of von Willebrand factor (vWF) via Gp1b

Which of the following steps of hemostasis is matched with the correct molecule involved in carrying out this function?

• Adhesion: 5-HT

• Shape change: vWF and Gp1b

• 1. Granule release: ADP, TXA2, 5-HT

• 1. Plug formation: NO and PGI2

Which receptor links platelets via fibrinogen?

• 1. GpIb

• 1. GpIIb/IIIa

• 1. vWF

• 1. TFPI

Which enzyme converts prothrombin to thrombin?

• 1. Thrombin calcium

• 1. Catalase

• 1. Thrombokinase calcium

• 1. Fibrinogen

Which endogenous anticoagulant is made by the liver and circulates in the plasma to block the action of Factor II, IX, X, XI, and XII?

• 1. Prostacyclin (PGi2)

• 1. NO

• 1. Heparin sulfate

• 1. Antithrombin III (ATIII)

Which endogenous anticoagulant is made by endothelial cells along blood vessels and inhibits TF/VIIa complex, Xa?

• 1. Thrombomodulin

• 1. Tissue Factor pathway inhibitor (TFPI)

• 1. Protein C

• 1. Plasmin

If there is a deficiency in this coenzyme, which of the following would cause clinically significant bleeding to occur?

• Vitamin B

• Vitamin C

• Vitamin K

• Vitamin A

Select all that apply: Virchow’s triad is made up of…

• 1. Endothelial injury

• 1. Vitamin K deficiency

• 1. Abnormal blood flow

• 1. Hypercoagulability