MAFLD and immune response

MAFLD is defined as a condition characterized by liver fat accumulation in the presence of which of the following metabolic conditions:

• Overweigth/Obesity

• T2DM

• Overweight/Obesity and T2DM

• Lean people and T2DM

Recruitment and activation of immune cells occurs preferentially at:

• Early stages of MASL(D)

• MASH stage of liver disease

• During MASLD and MASH

• Only at advanced stages, such as HCC

Which of the following is correct?

• KCs are characterized by expressing receptors for CD14 and TLR4

• IL-13 is a conventional TH1 cytokine

• Neutrophil elastase is not a constituent of NETs

• Monocyte-derived and embrionic-derived have the same function

What is the role of T cells in MAFLD late stages?

• CD4 T cells function as tumor inducers

• CD4 T cells function as tumor suppressors

• CD8 T cells function as tumor suppressors

• CD4 T cells can act as tumor inducer or suppressor, whilst CD8 T cells are only tumor suppressors

During gut dysbiosis, which of the following statements is correct?

• Bile acid synthesis decreases

• Gut-primed CD4 T cells reach the liver

• SCFA production is increased

• Increased phagocytic activity of CXCR3 macrophages in the gut