Gluconeogenesis (LM16)

1. The two major organs containing the full complement of gluconeogenic enzymes are:

• Brain and kidney

• Lung and liver

• Spleen and stomach

• Lung and brain

• Liver and kidney

2. The net transfer of carbon atoms from all of the following can be found in glucose, EXCEPT:

• Palmitate

• Lactate

• Propionate

• Glutamine

• Glycerol

3. Which compound below normally passes through the hepatic dicarboxylic acid shuttle on its way to forming glucose?

• Lactate

• Glycerol

• Urea

• Phosphoenolpyruvate

• Acetyl-CoA

4. Which one of the following enzymes catalyzes the rate-limiting reaction in gluconeogenesis?

• Pyruvate carboxylase

• PEP carboxykinase

• Fructose 1,6-bisphosphatase

• Enolase

• Glucose 6-phosphatase

5. Which one of the following is best associated with the stimulation of gluconeogenesis?

• Insulin

• Parathyroid hormone

• Cyclic-AMP

• Diacylglycerol

• Phosphodiesterase

6. Entry of propionate into gluconeogenesis requires vitamins:

• E and C

• B12 and biotin

• D and K

• Niacin and folate

• B6 and thiamin

7. Which hepatic gluconeogenic enzyme also functions in glycogenolysis?

• PEP carboxykinase

• Fructose 1,6-bisphosphatase

• Glycerol kinase

• Pyruvate carboxylase

• Glucose 6-phosphatase

8. Adipocytes contain all of the following gluconeogenic enzymes, EXCEPT (see Chapter 70):

• Pyruvate carboxylase

• PEP carboxykinase

• Glucose 6-phosphatase