Rheumatoid Arthritis (RA)

What is the etiology of rheumatoid arthritis?

• Inflammation of the joints

• Unknown

• Bacterial infection

• Viral infection

What is the pathophysiology of rheumatoid arthritis?

• Disregulation of humoral and cellular immune system

• Accumulation of plasma cells

• Release of vasoactive substances

• Genetic markers

Which of the following is a common manifestation of rheumatoid arthritis?

• Fever

• Headache

• Muscle pain

• Symmetrical polyarticular joint involvement

What is the goal of therapy for rheumatoid arthritis?

• To induce complete remission

• To reduce joint stiffness and pain

• To prevent systemic complications

• All of the above

Which of the following is not a DMARD used in the treatment of rheumatoid arthritis?

• Metotrexat

• Gold sodium thiomalate

• Penicillamine

• Ibuprofen

What is the mechanism of action of Leflunomide?

• Inhibition of cytokine production

• Inhibition of pyrimidine synthesis

• Inhibition of TNF-α

• Inhibition of IL-1 receptor

Which of the following is a side effect of Glukokortikoid therapy?

• Increased joint stiffness

• Suppression of the immune system

• Decreased inflammation

• Improved joint mobility

What is the role of Etanercept in the treatment of rheumatoid arthritis?

• Inhibition of cytokine production

• Inhibition of pyrimidine synthesis

• Inhibition of TNF-α

• Inhibition of IL-1 receptor

Which of the following is a potential complication of rheumatoid arthritis?

• Pleurisy

• Hypertension

• Diabetes

• Asthma

What is the recommended combination therapy for rheumatoid arthritis?

• NSAIDs and Glukokortikoids

• DMARDs and NSAIDs

• DMARDs and Glukokortikoids

• NSAIDs and Biologic DMARDs