Immunology exam 2 practice

Which of the following best characterizes the term “non-self,” resulting in the production of an immune
response?

• Healthy human cells

• Viruses

• Non-infected macrophages

From the following ligands, which can CR-3 and CR-4 recognize?

• Nucleic acids
  

• C3b

• LPS

• A & B

Identify the macrophage receptor(s) necessary for the process of phagocytosis

• CCRs & CXCRs
  

• Scavenger receptors

• Toll-like receptors

• none of the above

Which of the following statements about macrophages is incorrect

• They are expected to reside within the tissues

• They remain in circulation until an infection breaches the first lines of defense

• They can function in both innate and adaptive immune responses

• all of the above

Tags

NGSS.HS-LS1-4

TLR-4 is considered a _____ and recognizes a _____, such as LPS

• PRR ; PAMP
  

• PAMP ; PRR

All of the following are cytokines, except:

• IL-1

• TNF-a

• MDA-5

• IL-6

In class, we discussed several inflammatory cytokines that are secreted by macrophages after the recognition
of pathogen. Which of the following was NOT included in that discussion?

• IFN-y

• IL-6

• IL-1B

• CCL-2

Which innate cytoplasmic receptor is expected to recognize degradation products of bacteria? In other words,
identify the receptor below that would recognize an intracellular bacterial infection within the cytoplasm

• NOD-1

• MDA-5

• RIG-1

• B and C

Which of the following statements is correct about type I interferon?

• They belong to the same class (family) as IFN-y
  

• They are only secreted by NK cells, CD8 T cells, and TH1 cells

• Their secretion is a direct response to a viral infection

• here is only one isotype of type I interferon

Which of the following inflammatory cytokines is paired incorrectly with its role/function?

• IL-6 : generates a rise in temperature

• TNF-a : leads to an increase in vascular permeability

• IL-12 : signals hepatocytes to produce acute-phase reactants

• CCL-2 : involved in the recruitment of circulatory monocytes to the infected tissues