
JMML Young Ewog
Authored by Edoardo Muratore
Biology
University
Used 4+ times

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7 questions
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1.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following signs is RARELY observed in JMML
splenomegaly
cough
CNS infiltration
rash
fever
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following PB/BM smear pairs is more likely to correspond to the JMML patient?
A
B
C
D
E
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of these features are considered high risk?
WBC 35x10e9
Plt 53x10e9
HbF 23%
4% of monoblasts
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What single test will be more helpful at this stage?
Karyotyping
GM-CSF cell culture
Molecular diagnosis of Ras pathway mutations and BCR/ABL exclusion
Methylation profiling
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of these statments about somatic PTPN11 is FALSE
it is the most common mutation in JMML
usually has lower age of presentation
is often self-limiting, "watch and wait“ strategy is possible
usually found in high methylation group
6.
MULTIPLE SELECT QUESTION
45 sec • 1 pt
What would be your first therapeutic intervention in this case?
Upfront HSCT without prior therapy
AML-like induction therapy
Fludarabine and cytarabine
6 Mercaptopurine
Azacitidine
7.
MULTIPLE SELECT QUESTION
45 sec • 1 pt
How would you condition this patient if a MUD 10/10 is available?
Treosulfan, Cyclophosphamide and Melphalan
Busulfan, Cyclophosphamide and Melphalan
Busulfan and Fludarabine
Busulfan, Fludarabine and Melphalan
Treosulfan, Fludarabine and Melphalan
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