HaDPop Session 7: RCT

Clinical trials provide reliable evidence of the efficacy and ______ of a treatment

• Cost

• Safety

• Reliability

• Reproducibility

To achieve this a clinical trial needs to be:

• 1. Fair

  2. Safe

  3. Variable

• 1. Fair

  2. Cheap

  3. Reproducible

• 1. Biased

  2. Controlled

  3. Unique

• 1. Fair

  2. Controlled

  3. Reproducible

Randomisation of participants to treatment groups within a clinical trial minimises the risk of which type of bias?

• Allocation bias

• Selection bias

• Placebo bias

• Attrition bias

What is a placebo?

• The active formulation but given at a higher dose

• The active formulation but given at a lower dose

• An inert substance made to appear identical to the active formulation

• Preventing a person involved in the study from knowing which treatment a participant is receiving

Intention to treat (ITT) analysis of a clinical trial means which of the following?

• Participants should not be enrolled unless they really intend to take the treatment

• All participants allocated to a study group must be included in the final analysis of that group regardless of whether they completed the treatment

• All participants allocated to a study group are included in the final analysis of that group regardless but only only if they completed the treatment

• All participants must agree to be randomly allocated and take the treatment they have been assigned