Lecture 19

Which is not an alternative to "non-druggable" protiens

• Knock out genes

• Silence the mRNA

• Tag the protein

• Inject the protein

How is CRISPR utilized in AIDS treatment

• CRISPR cannot be used

• Specifically targeted to a single gene

• Cut up the virus walls

• via mRNA

Which is not a Steric Hindrance type of antisense therapeutics?

• Splicing modulation (exon skipping/inclusion)

• Allele-specific mRNA cleavage

• Translational arrest

What is an advantage of antibodies as drugs?

• Cannot enter the brain

• Only targets the surface-exposed proteins

• Cannot penetrate into dense tumors

• More target specific

___________ is a spherical-shaped vesicle that is composed of one or more phospholipid bilayers.