Test9MyelodysplasticMDS

This syndrome is a neoplastic PSC disorder of the bone marrow caused by somatic mutation(s)/chromosome abnormalities.

• Chromosomal Plastic Syndrome (CPS)

• Myelodysplastic Syndromes (MDS)

• Thrombocyte Syndrome (TS)

• Polycythemia Vera Syndrome (PVS)

Myelodysplastic Syndromes (MDS) is characterized by

• reactive leukocytosis and leukemoid reaction

• plasma cell and neoplasms

• bacterial infection and thrombocytopenia

• dysmyelopoiesis and peripheral blood cytopenias

Dyspoiesis/dysplasia has

• maturation abnormalities

• cytoplasm looks weird

• increased cell death

• marrow is stringy tissue is less

Nuclear-cytoplasmic asynchrony the

• maturation abnormalities

• cytoplasm looks weird

• increased cell death

• marrow is stringy tissue is less

In ineffective hematopoiesis the

• maturation abnormalities

• cytoplasm looks weird

• increased cell death

• marrow is stringy tissue is less

In increased apoptosis their is

• maturation abnormalities

• cytoplasm looks weird

• increased cell death

• marrow is stringy tissue is less

Characteristics of MDS

Most common in ​ (a)   population

Most often ​ (b)   ; lymphoid linage ​ (c)   affected

​ (d)   , myeloid, and/or ​ (e)   lineages

• elderly
• myeloid
• rarely
• Erythroid
• megakaryocytic
• younger
• always
• crystoid
• megaladon
• megalodon

Characteristics of MDS (cont.)

​ (a)   BM with PB ​ (b)  

Cells have abnormal ​ (c)   and ​ (d)   function

WHO criterion for MDS dx: ​ (e)   in any hematopoietic lineage

• Hyperplastic
• cytopenias
• morphology
• compromised
• 10% dysplastic cells
• Hypoplastic
• myeloidopenia
• protect

What are the two types of MDS?

• Primary and Secondary

• Tertiary and Primary

• Secondary and Tertiary

• Primary and Primary 2

Choose all that apply to Primary MDS.

• 60-70% of MDS cases

• abnormal stem cell arises without known prior exposure to damaging agent

• Genotoxic chemicals

  Radiation

  Viral infection

• bacterial infection

  therapy-related