Test4anemia2

Normally, ​ (a)   taken up by ​ (b)   precursors is either ​ (c)   into heme within the RBC ​ (d)   .

• most iron
• erythroid
• incorporated
• mitochondria or stored

Which of these is not iron storage for Ferritin?

• protein that stores iron in the short-term

• allows iron to be readily available for erythropoiesis

• controls amount of iron released for cellular activity

• fat that stores iron in the long-term

• found in the BM, liver, spleen-stains with Perl's Prussian Blue (specific for Fe)

Match the following descriptions.

• Serum levels reflect tissue storage; caution: APR! (Acid Phase Reactant)

• Iron deficiency anemia

• microcytic, hypochromic, anisocytosis, poikilocytosi

• Ferritin

• dual population of normochromic and hypochromic erythrocytes

• Anemia of chronic disease

• normocytic, normochromic in long-standing cases can be microcytic, hypochromic

• Sideroblastic Anemia

• long-term storage for iron; iron released more slowly

• Hemosiderin

Match the following pictures to their correct description.

• yellow to brown refractile inclusions

• 
• Koilonychia (concavity of nails)

• 
• Prussian blue stain reveals ringed sideroblasts

• 
• Glossitis

• 
• stains with Prussian blue

• 

BM and liver macrophages primarily contain___.

• hemosiderin

• inclusions

• vitamin C

• Gloittis

For Iron Balance Daily absorption and loss are ​ (a)  

Lose ~1 mg per day

​ (b)   of RBCs are destroyed each day

Releases ​ (c)   of iron but most is recycled

Daily requirement for iron is​ (d)  

No physiologic route for ​ (e)   excess iron

• small
• 20-25 mL
• 20-30 mg
• 1 mg
• excreting

Reorder the following Daily iron cycle.

• Most iron is recycled from the erythrocytes to macrophages in the bone marrow.

• Only a small amount of iron is lost from the body through loss of iron-containing cells.

• To maintain iron balance, a similar amount of iron is absorbed from the duodenum.

• Macrophages release iron as needed to the developing erythroid cells in the bone marrow.

a

b

c

d

e

f

Mucosa cells in duodenum absorption

loss

Erythroid marrow

Hepatocytes

Iron

bone marrow macrophage

Match the following

• Wright-Giemsa stain

• 
• Pappenheimer Bodies

• 
• Mild anemia

  Hgb not <9.0g/dL

  Hct not <27%

• Peripheral blood

• Basophilic stippling

• 
• macrophages with abundant blue staining iron

• 

​ (a)   usually ​ (b)   unless long-standing

MCV ​ (c)  

​ (d)   and ​ (e)   usually normal unless underlying disease causes defect

• RBCs
• normocytic
• >85fL
• WBC
• PLT