FC and NAS

Which statement regarding the limitations/conditions of Friedel- Crafts Alkylation is false?

• Works on deactivated rings

• Overalkylation can lead to unexpected products

• Works on activated rings

• Rearrangements in carbocations can lead to unexpected products

Which statement regarding Friedel-Crafts Acylation is false?

• The reagents needed to reduce an acyl group are Zn(Hg) + HCl(aq)

• 
• Acylation does not work on deactivated rings

• Overacylation can lead to unexpected products

Which statement regarding Nucleophilic Aromatic Substitution (NAS) is TRUE?

• 
• NAS requires a leaving group

• NAS happens by SN2

• The rate limiting step of Addition-Elimination NAS is the elimination

Which statement regarding NAS is FALSE?

• There must be a strong nucleophile present for NAS to occur

• NAS Addition-Elimination happens faster with EWG's

• Ortho/meta/para directors apply in NAS

• In NAS, benzene acts as an electrophile

Which statement regarding the benzyne mechanism is FALSE?

• It follows an elimination-addition mechanism

• It works on deactivated rings

• The creation of a triple bond leads to multiple products

• The strong nucleophile in solution first acts as a base

The 3 requirements for the benzyne mechanim are:

• An activated/

  nondeactivated ring

• Nucleophilic Reagents

• A deactivated ring

• A leaving group

The 3 requirements for the Addition-Elimination mechanism are:

• A leaving group

• A deactivated ring

• An activated/

  nondeactivated

  ring

• Nucleophilic reagents

Draw your favorite common benzene derivative :)