What is the general mechanism of nucleophilic acyl substitution?
Chapter 4 CHM132

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Chemistry
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University
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Medium
DR NOR WAHIDA
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10 questions
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1.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
One-step SN1-type mechanism
Two-step: nucleophilic attack followed by leaving group departure
Acid–base neutralization
Rearrangement reaction
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following is the best leaving group among carboxylic acid derivatives?
NH₂⁻
OH⁻
OR⁻
Cl⁻
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Arrange the following leaving groups from poorest to best in nucleophilic acyl substitution:
OH⁻ < NH₂⁻ < RCOO⁻ < OR⁻ < Cl⁻
NH₂⁻ < OH⁻ < OR⁻ < RCOO⁻ < Cl⁻
Cl⁻ < RCOO⁻ < OR⁻ < OH⁻ < NH₂⁻
RCOO⁻ < Cl⁻ < OH⁻ < NH₂⁻ < OR⁻
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Why is a carboxylic acid (R–COOH) less reactive than an acid chloride (R–COCl)?
Cl⁻ is more electronegative than OH⁻
OH⁻ is a weaker acid
OH⁻ is a poor leaving group compared to Cl⁻
Carboxylic acids do not contain a carbonyl group
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is the product when an ester reacts with ammonia (NH₃)?
Carboxylic acid
Amide
Ketone
Aldehyde
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Why are amides generally the least reactive among carboxylic acid derivatives?
Amides do not contain a leaving group
The carbonyl group in amides is unstable
NH₂⁻ is a poor leaving group due to its strong basicity
Amides are charged species and unreactive in water
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is the product of this hydrolysis reaction: R–COCl + H₂O → ?
R–CH₃
R–COOH
R–OH
R–COOR
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