Fibrinolysis

A primary inhibitor of the fibrinolytic system is:

• alpha-2 antiplasmin

• alpha-2 macroglobulin

• antithrombin

• Protein C

D-dimers are elevated in which of the following conditions?

• Primary fibrinolysis

• Deep vein thrombosis

• hemophilia A

• Glanzmann's thrombasthenia

All of the following are functions of thrombin except:

• Activating factors V, VIII, and XIII

• Activating platelets

• Activating thromboplastin

• Converting fibrinogen to fibrin

Which of the following is the best possible treatment for a patient with DIC?

• Provide supporting blood products

• Give the patient tPA if there is excessive clotting

• Resolve the underlying cause of DIC

• Give the patient heparin therapy

What is the primary purpose of the fibrinolytic system?

• To form a stable fibrin clot

• to activate the complement system

• to restore blood flow at the local level

• to inhibit coagulation

Which of the following is true in the condition known as DIC?

• FV and FVIII become increased in activity

• fibrinolytic activity is absent

• the patient has a single coagulation factor deficiency

• Fibrinogen and platelets become depleted

D-dimer formation is the result of the action of plasmin on:

• fibrin monomer

• fibrinogen

• cross-linked fibrin

• FDPs

In primary fibrinolysis, which of the following lab tests will be abnormal?

• Platelet count

• d-dimer

• fibrinopeptide A level

• Thrombin Time

The primary tissue source for tissue plasminogen activator (tPA) is:

• Streptococcal bacteria

• Kidney

• Endothelial cells

• Pluripotential stem cells

Unregulated and excessive formation of thrombin and plasmin is seen in:

• Liver disease

• vitamin K deficiency

• primary fibrinolysis

• DIC