Quiz2_QSAR

What does the symbol P represent in a QSAR equation?

• pH

• Partition coefficient

• Plasma concentration

• Prodrug

What is the symbol π in a QSAR equation?

• The hydrophobicity of the molecule

• The electronic effect of a substituent

• The substituent hydrophobicity constant

• A measure of the steric properties for a substituent

Calculate the logP value of p- Hydroxy toluene if logP for benzene = 2.13; π(OH) -0.67; π(CH3) 0.52.

• 3.32

• 0.94

• 1.98

• 2.13

What does MR represent in a QSAR equation?

• Molar refractivity is a steric factor

• Molar refractivity is an electronic factor

• Molar refractivity is a hydrophobic factor

• Molar refractivity is a stereoelectronic factor

What software programme is used to determine the Verloop steric parameter?

• Alchemy

• Chem3D

• Sterimol

• ChemDraw

What does a positive value of σ signify for a substituent?

• It is electron donating

• It is electron withdrawing

• It is neutral

• t is hydrophobic

A negative π value indicates

• higher lipophilicity

• lower lipophilicity

• electron with drawing group

• electron donating group

Electronic effects can be represented as a

• function of field(inductive) effect

• function of a resonance effect

• function of mesomeric effect

• linear combination of field(inductive) effect and a resonance effect

Atoms or groups possess +I effect is they

• donate electrons to carbon atom

• withdraw electrons to carbon atom

• can form H-bond

• can release OH^- ion

Which of the following is not a steric parameter?

• Partition coefficient

• Molar Refractivity

• Parachor

• verloop steric parameter