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1.
FLASHCARD QUESTION
Front
What is tolerance in pharmacology?
Back
Tolerance is a phenomenon where the response to a drug decreases over time, requiring higher doses to achieve the same effect. It typically develops over days to weeks.
2.
FLASHCARD QUESTION
Front
What is tachyphylaxis?
Back
Tachyphylaxis is a rapid decrease in response to a drug after its administration, often occurring after the first dose.
3.
FLASHCARD QUESTION
Front
How should a low TI drug be dosed for different weights?
Back
For a low therapeutic index (TI) drug, a higher mg/kg dose should be given to lighter animals compared to heavier ones.
4.
FLASHCARD QUESTION
Front
What happens to drug metabolism in very old animals?
Back
In very old animals, drug metabolism typically decreases due to reduced activity of cytochrome P450 enzymes.
5.
FLASHCARD QUESTION
Front
What is the effect of liver failure on drug metabolism?
Back
In liver failure, there is often a decrease in bile secretion, which can affect drug metabolism and clearance.
6.
FLASHCARD QUESTION
Front
What is biliary excretion?
Back
Biliary excretion is the process by which drugs are excreted into bile and can be eliminated from the body.
7.
FLASHCARD QUESTION
Front
What is enterohepatic circulation?
Back
Enterohepatic circulation is the recycling of drugs and metabolites between the liver and the intestine, which can prolong the drug's effect.
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