Pharm Tox Exam 3

Front

At which phase are most cancer cells resistant to anticancer agents? Options: G1 phase, G0 phase, G2 phase, S phase

Back

G0 phase

Front

Which compound/structure is relevant to the development of cancer for chimney sweepers?

Back

Benzo [a] pyrene

Front

Which of the follow is incorrect regarding chemotherapy as its use in cancer treatment? Chemotherapy may be used to help reduce the size of a tumor prior to surgery. Chemotherapy is very effective because it is selective for and recognizes cancer cells readily. Chemotherapy has a lot o use to eliminate small tumors, but not very good for large tumors because of the lack of perfusion. Chemotherapy takes advantage of cancer cells because they rapidly take up more "stuff" for proliferation, which in turn leads to cancer cells taking up more of the agent!

Back

Chemotherapy is very effective because it is selective for and recognizes cancer cells readily

Front

What is the "key step" of most alkylating agents to be effective as an anticancer agent?

Back

The formation of the aziridinium ion which forms a good leaving group.

Front

Which of the following aspect is incorrectly matched with its category of anticancer agent? Procarbazine utilizes a free methyl radical as its reactive species / alkylating agent, Nitrosourea's final alkylating agent is a vinyl cation which is very reactive as it contains a positive charge. This is considered a "key" step, Cistplatin/Carboplatin can NOT be used with aluminum containing needles due to precipitation and loss of potency, Cytarabine is unique because it only has one specific mechanism of action, compared to most anticancer agents having multiple MoAs

Back

Cytarabine is unique because it only has one specific mechanism of action, compared to most anticancer agents having multiple MoAs

Front

Which enzyme does dactinomycin and other antimitotic agents (eg. anthracyclines, etoposide, etc.) target?

Back

Topoisomerase II

Front

Which correctly describes the relationship between GnRH agonists and antiandrogens and how they are used as anticancer agents? Options: When administering GnRH agonists, there will be a chronic increase in testosterone levels, which overwhelms cancer cells and leads to cell death; We administer an antiandrogen agent with a GnRH agonist to block the initial surge of testosterone, to avoid an increased risk of cell proliferation with increased levels of testosterone; Leuprolide and Goserelin immediately decrease testosterone to castrate levels, which overall will decrease proliferation of cancer cells; Studies have shown that an increase in estrogen synthesis by aromatase leads to decreased cell proliferation. This is why there has been development looking at induction of the aromatase enzyme.

Back

We administer an antiandrogen agent with a GnRH agonist to block the initial surge of testosterone, to avoid an increased risk of cell proliferation with increased levels of testosterone.

Front

Which drug is an inhibitor of thymidylate synthase?

Back

5-FU

Front

T/F: NAD+ is used as a reactant in the general monooxygenase reaction?

Back

False

Front

Which enzyme contains a heme group? Options: CYP, UGT, MOA, SULTs

Back

CYP