Immuno End of chapter questions

Front

What is the immune phenomenon associated with the Arthus reaction?

Back

Deposition of immune complexes in blood vessels.

Front

What does epitope spreading refer to?

Back

Expansion of the immune response to unrelated antigens.

Front

Which of the following properties is not exhibited by HLA molecules?

Back

They are monomorphic.

Front

What immune mechanisms are involved in type III hypersensitivity reactions?

Back

Deposition of immune complexes occurs in antibody excess.

Front

What does the indirect allorecognition pathway involve?

Back

Processed peptides from polymorphic donor proteins restricted by recipient HLA class II molecules.

Front

Define type III hypersensitivity.

Back

A hypersensitivity reaction characterized by the formation of immune complexes that deposit in tissues, leading to inflammation and tissue damage.

Front

What is the role of HLA molecules in the immune system?

Back

HLA molecules present antigens to T cells, playing a crucial role in the immune response.

Front

Explain the concept of immune complexes.

Back

Immune complexes are formed when antibodies bind to soluble antigens, which can lead to tissue damage if deposited in blood vessels.

Front

What is the significance of polymorphism in HLA molecules?

Back

Polymorphism allows for a diverse range of antigens to be presented to T cells, enhancing the immune response.

Front

Describe the mechanism of action in type III hypersensitivity.

Back

In type III hypersensitivity, immune complexes form and deposit in tissues, activating complement and attracting inflammatory cells.