Macroautophagy | Regulation During Feeding, Fasting and Starvation

The video explores how fasting regulates macroautophagy, a process of cellular degradation and recycling. It explains the role of macroautophagy in energy generation during fasting and details the pathway involving autophagosomes and lysosomes. The regulation by mTOR and AMPK is discussed, highlighting their influence on autophagy activation. Nuclear changes during fasting, including the roles of transcription factors like TFEB, ZKSCAN3, and FXR, are covered. The video also touches on the JNK pathway's role in autophagic trafficking. Finally, it summarizes the effects of short-term and prolonged fasting on macroautophagy and chaperone-mediated autophagy.

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