Lysine Catabolism to Glutaryl-S-CoA

The video tutorial explains lysine catabolism in mammals, highlighting its convergence with tryptophan catabolism through the production of alpha keto adipate. It details the role of enzymes like lysine alpha ketoglutarate reductase and saccharopine dehydrogenase in the pathway, emphasizing the unique consumption of NADPH. The tutorial also covers the function of alpha amino adipate 6-semialdehyde dehydrogenase, which is expressed in multiple cell compartments. The process ultimately leads to the production of acetyl CoA, classifying lysine as a purely ketogenic amino acid, alongside leucine.

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