Omega Oxidation for Fatty Acids

The video tutorial explains Omega oxidation, a fatty acid catabolic pathway, and its significance, especially when beta oxidation enzymes are defective. It occurs in the smooth ER of the liver and kidneys, primarily on medium-chain fatty acids. The process involves three steps: hydroxylation, oxidation to an aldehyde, and oxidation to a carboxylic acid, yielding NADH. The resulting dicarboxylic acid is ligated to Coenzyme A and undergoes beta oxidation, producing energy and intermediates like succinyl COA, which enters the citric acid cycle.

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