The Surprising Difficulties of Off-Label Prescriptions

The video discusses the legal and prevalent practice of off-label drug use, highlighting the lack of incentives for conducting costly clinical trials to test these uses. It explains the risks associated with off-label prescriptions, such as increased adverse events, and contrasts the incentives for developing new drugs with those for finding new uses for existing ones. The video provides examples of drugs with new uses discovered accidentally or through public research. It suggests solutions like government-sponsored studies and technological systems to track prescriptions, aiming to encourage safer off-label discoveries and address the free rider problem.

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