Psychoneuroimmunology | How Stress and Depression Make You Sick

The video explores the relationship between major depressive disorder (MDD) and the immune system, a field known as psychoneuroimmunology. It discusses how MDD can lead to immunological dysfunction, affecting T cell and natural killer cell activity. The video outlines the diagnostic criteria for MDD using the mnemonic McGee caps. It explains how stress impacts immune function, leading to increased cytokine production and altered immune responses. The video also examines how changes in the immune system can increase the risk of developing MDD, highlighting the role of cytokines and cortisol in reducing serotonin levels. Finally, it discusses the outcomes of immunomodulation, including associations with autoimmune diseases and infections.

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