What's the Most Bitter Chemical

Denatonium, the most bitter compound known, was discovered accidentally in 1958 during lidocaine research. While not a better anesthetic, it binds to bitter taste receptors, making it extremely bitter. Marketed as Bitrex, it holds the Guinness World Record for bitterness. Denatonium is used in products to prevent ingestion, such as Nintendo cartridges and nail polish. It is non-toxic and unreactive, making it ideal for safety applications. Research suggests it may aid in digestion and respiratory health, offering potential medical benefits.

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