Prions | Mechanisms of Huntington's Disease & the Huntingtin Prion

The video explains Huntington's disease, focusing on its genetic basis, particularly the role of GTC repeats in the Huntington gene. It describes how these repeats lead to protein misfolding, forming prions that disrupt cellular functions. The disease primarily affects the basal nuclei, impairing movement control. Misfolded proteins cause cellular dysfunction, leading to neuron death and disease progression. The video also compares Huntington's with other prion diseases like Parkinson's and Alzheimer's, highlighting similar mechanisms.

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