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The video covers top headlines for March 25th, including the Colorado supermarket shooting where a 21-year-old suspect will appear in court. Over 500 people gathered in Boulder to mourn the victims. President Biden is set to hold his first news conference, addressing issues like mass shootings, the border situation, and the pandemic. The Biden administration's media strategy has faced criticism from Republicans. AstraZeneca updated its COVID-19 vaccine efficacy to 76% after recalculating data, addressing concerns from health officials. The company plans to seek FDA approval soon.

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